| Am 21.03.2001 um 01:33:49 schrieb Monika Draga (ForenMaster):
Bisherige Studien
Hier der aktuelle Stand aus MedLine (National Library of Medicine):
TITLE: Patients with fibromyalgia have normal serum levels of hyaluronic acid.
AUTHORS: Bliddal H; Moller HJ; Schaadt M; Danneskiold-Samsoe B
AUTHOR AFFILIATION: Department of Rheumatology, Frederiksberg Hospital, Copenhagen, Denmark. henning.bliddal@fh.hosp.dk
SOURCE: J Rheumatol 2000 Nov;27(11):2658-9.
[MEDLINE record in process]
CITATION IDS: PMID: 11093449 UI: 20543778
ABSTRACT: OBJECTIVE: To investigate the levels of hyaluronic acid (HA) in Danish patients with fibromyalgia (FM). METHODS: Serum levels of HA were determined in 53 patients with established FM and 55 control samples using a radiometric assay. Values were correlated to clinical disease severity variables (duration of disease, tender point scales, visual analog scales). RESULTS: There were no differences in HA levels between patients and controls. HA levels of all patients except one were within the reference ranges. There was no association between HA levels and clinical findings. CONCLUSION: Patients with FM do not generally have increased serum levels of HA.
TITLE: Elevated levels of hyaluronic acid in the sera of women with fibromyalgia.
AUTHORS: Barkhuizen A; Bennett RM
SOURCE: J Rheumatol 1999 Sep;26(9):2063-4.
CITATION IDS: PMID: 10493694 UI: 99421437
COMMENT ON: J Rheumatol. 1997 Nov;24(11):2221-4
TITLE: Elevated levels of hyaluronic acid in the sera of women with fibromyalgia.
AUTHORS: Yaron I; Buskila D; Shirazi I; Neumann L; Elkayam O; Paran D; Yaron M
AUTHOR AFFILIATION: Department of Rheumatology, Souraski Tel Aviv Medical Center, Tel Aviv University Sackler School of Medicine, Israel.
SOURCE: J Rheumatol 1997 Nov;24(11):2221-4.
CITATION IDS: PMID: 9375887 UI: 98041735
COMMENT IN: J Rheumatol. 1999 Sep;26(9):2063-4
ABSTRACT: OBJECTIVE: To evaluate serum levels of hyaluronic acid (HA) in patients with fibromyalgia (FM). METHODS: HA serum levels were evaluated by a radiometric assay in 42 women with FM (ACR criteria), 27 female patients with rheumatoid arthritis (RA) and 36 healthy female controls matched for age. RESULTS: HA serum levels (mean microg/l +/- SEM) were 41 +/- 8.7 in healthy controls; 113 +/- 15.9 in RA: and 420 +/- 26 in FM. CONCLUSION: HA serum levels in women with FM were significantly elevated compared to healthy controls and patients with RA. This observation suggests that FM is associated with a biochemical abnormality and that serum HA could be a laboratory marker for its diagnosis.
Nachdem nun drei Arbeiten aus drei Kontinenten vorliegen, sieht die Bilanz so aus: Erhöhte Werte wurden gefunden bei der Studie in Israel, während in USA und in Dänemark dieses Ergebnis nicht bestätigt werden konnte. Stellt sich für mich die Frage, wie es dazu kommen kann. Die Studie aus Dänemark habe ich noch nicht in der Vollversion gelesen. Vielleicht steht da ja etwas darüber drin, wann und unter welchen Bedingungen die Untersuchungen stattgefunden haben. Alle zur gleichen Zeit? Nur eine Probe von jedem Patienten? Oder mehrere über einen gewissen Zeitraum verteilt?
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